Cardiotoxicity of chloroquine in rabbits
Identifieur interne : 003D09 ( Main/Exploration ); précédent : 003D08; suivant : 003D10Cardiotoxicity of chloroquine in rabbits
Auteurs : M. Kubašta [Tchécoslovaquie] ; M. Vykydal [Tchécoslovaquie] ; A. Zmeškal [Tchécoslovaquie] ; I. Gikalovová [Tchécoslovaquie]Source :
- Archiv für Toxikologie [ 0003-9446 ] ; 1967-09-01.
English descriptors
- Teeft :
- Atrial fibrillation, Auricular fibrillation, Blood pressure, Body weight, Cardiac muscle, Cardiotoxicity, Chloroquine, Chloroquine administration, Chloroquine concentrations, Complete block, Direct action, Dos, Ehloroquine, Electric activity, Electric potentials, Experimental animals, Fatal poisonings, Fibrillation, General thiopental anaesthesia, Immediate concentration, Important effect, Infusion, Intramuscular administration, Intravenous, Intravenous administration, Intravenous injection, Nivaquine, Normal saline, Oral administration, Prolongation, Rapid administration, Respiratory arrest, Respiratory center, Seconds auricular arrest, Seconds deformation, Slow infusion, Small overdosage, Temporary interruption, Total amount, Ultraviolet spectrophotometry, Various tissues, Ventricular, Ventricular arrest, Ventricular fibrillation, Ventricular tachycardia.
Abstract
Summary and Conclusions: Chloroquine administered intravenously to rabbits has an immediate and direct action on the heart muscle. Following doses of 15 mgm to 40 mgm of base per kg of body weight administered within from one second to 24 minutes the following consecutive ECG changes occurred: deformation of the S-T segment and deformation and flattening of the T wave, prolongation of the Q-T interval, prolongation of the P Q interval, widening of the QRS complex, complete atrio-ventricular block, ventricular standstill, ventricular extrasystoles, ventricular tachycardia, ventricular fibrillation. The immediate causes of deaths were ventricular arrest or fibrillation. The respiratory arrest was only secondary, probably due to anoxia of the respiratory center. With temporary interruption of the chloroquine infusion even serious ECG changes passed very quickly and seemed to depend on the immediate concentration of the drug in the blood flowing through the myocardium. This action of chloroquine on the heart may have accounted for sudden deaths in poisonings from ingestion of larger doses of the drug in man. Intravenous administration of chloroquine to man is thought to be hazardous. Even increasing the daily amount of the drug given by mouth may not be without risk.
Url:
DOI: 10.1007/BF00577589
Affiliations:
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Zmeškal</name><affiliation wicri:level="1"><country xml:lang="fr">Tchécoslovaquie</country><wicri:regionArea>Third Department of Medicine, Medical Faculty, Palacký University, Olomouc</wicri:regionArea><wicri:noRegion>Olomouc</wicri:noRegion></affiliation></author><author><name sortKey="Gikalovova, I" sort="Gikalovova, I" uniqKey="Gikalovova I" first="I." last="Gikalovová">I. Gikalovová</name><affiliation wicri:level="1"><country xml:lang="fr">Tchécoslovaquie</country><wicri:regionArea>Third Department of Medicine, Medical Faculty, Palacký University, Olomouc</wicri:regionArea><wicri:noRegion>Olomouc</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Archiv für Toxikologie</title><title level="j" type="abbrev">Arch. Toxikol.</title><idno type="ISSN">0003-9446</idno><idno type="eISSN">1432-0738</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1967-09-01">1967-09-01</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="373">373</biblScope><biblScope unit="page" to="380">380</biblScope></imprint><idno type="ISSN">0003-9446</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-9446</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Atrial fibrillation</term><term>Auricular fibrillation</term><term>Blood pressure</term><term>Body weight</term><term>Cardiac muscle</term><term>Cardiotoxicity</term><term>Chloroquine</term><term>Chloroquine administration</term><term>Chloroquine concentrations</term><term>Complete block</term><term>Direct action</term><term>Dos</term><term>Ehloroquine</term><term>Electric activity</term><term>Electric potentials</term><term>Experimental animals</term><term>Fatal poisonings</term><term>Fibrillation</term><term>General thiopental anaesthesia</term><term>Immediate concentration</term><term>Important effect</term><term>Infusion</term><term>Intramuscular administration</term><term>Intravenous</term><term>Intravenous administration</term><term>Intravenous injection</term><term>Nivaquine</term><term>Normal saline</term><term>Oral administration</term><term>Prolongation</term><term>Rapid administration</term><term>Respiratory arrest</term><term>Respiratory center</term><term>Seconds auricular arrest</term><term>Seconds deformation</term><term>Slow infusion</term><term>Small overdosage</term><term>Temporary interruption</term><term>Total amount</term><term>Ultraviolet spectrophotometry</term><term>Various tissues</term><term>Ventricular</term><term>Ventricular arrest</term><term>Ventricular fibrillation</term><term>Ventricular tachycardia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary and Conclusions: Chloroquine administered intravenously to rabbits has an immediate and direct action on the heart muscle. Following doses of 15 mgm to 40 mgm of base per kg of body weight administered within from one second to 24 minutes the following consecutive ECG changes occurred: deformation of the S-T segment and deformation and flattening of the T wave, prolongation of the Q-T interval, prolongation of the P Q interval, widening of the QRS complex, complete atrio-ventricular block, ventricular standstill, ventricular extrasystoles, ventricular tachycardia, ventricular fibrillation. The immediate causes of deaths were ventricular arrest or fibrillation. The respiratory arrest was only secondary, probably due to anoxia of the respiratory center. With temporary interruption of the chloroquine infusion even serious ECG changes passed very quickly and seemed to depend on the immediate concentration of the drug in the blood flowing through the myocardium. This action of chloroquine on the heart may have accounted for sudden deaths in poisonings from ingestion of larger doses of the drug in man. Intravenous administration of chloroquine to man is thought to be hazardous. Even increasing the daily amount of the drug given by mouth may not be without risk.</div></front></TEI><affiliations><list><country><li>Tchécoslovaquie</li></country></list><tree><country name="Tchécoslovaquie"><noRegion><name sortKey="Kubasta, M" sort="Kubasta, M" uniqKey="Kubasta M" first="M." last="Kubašta">M. Kubašta</name></noRegion><name sortKey="Gikalovova, I" sort="Gikalovova, I" uniqKey="Gikalovova I" first="I." last="Gikalovová">I. Gikalovová</name><name sortKey="Vykydal, M" sort="Vykydal, M" uniqKey="Vykydal M" first="M." last="Vykydal">M. Vykydal</name><name sortKey="Zmeskal, A" sort="Zmeskal, A" uniqKey="Zmeskal A" first="A." last="Zmeškal">A. Zmeškal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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